Description

L-Proline, 4-(Fluoromethylene)-, (E)- (9Ci) is a high-value, non-natural amino acid derivative featuring a strategically positioned fluoromethylene group. This compound is a critical chiral building block in modern organic synthesis and pharmaceutical research, enabling the introduction of fluorine to modulate the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel bioactive compounds and peptidomimetics.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the synthesis of fluorinated drug candidates, particularly protease inhibitors and receptor modulators.
• Peptidomimetics Research: Used to incorporate fluorinated proline analogs into peptide backbones to study conformation, stability, and protein-protein interactions.
• Agrochemical Development: Employed in creating novel, fluorinated active ingredients with potentially enhanced efficacy and environmental profile.
• Chemical Biology Probes: Acts as a building block for fluorinated amino acids used in 19F NMR spectroscopy and other bioimaging techniques.
• Material Science: Investigated for the synthesis of specialized fluorinated polymers and foldamers with unique structural properties.

Basic Information

Product Name	L-Proline, 4-(Fluoromethylene)-, (E)- (9Ci)
CAS No.	138958-01-7
Molecular Formula	C6H8FNO2
Molecular Weight	145.13 g/mol
Synonyms	(2S)-4-(Fluoromethylene)pyrrolidine-2-carboxylic acid; (E)-4-(Fluoromethylene)-L-proline; (E)-4-Fluoromethylene-L-proline; 4-(Fluoromethylene)-L-proline; L-4-(Fluoromethylene)proline; (E)-Isomer of 4-Fluoromethylene-L-proline; Fluorinated L-Proline Derivative; CAS 138958-01-7
EINECS	Contact for details

Quality Control

Every batch of L-Proline, 4-(Fluoromethylene)-, (E)- (9Ci) is manufactured under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency for research and development applications. A detailed Certificate of Analysis (COA) including results for chiral purity, assay, and related substances is supplied with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.