Description

D-Threo-Chloramphenicol, [Dichloroacetyl-1-14C] CAS NO 138879-88-6 is a carbon-14 radiolabeled derivative of the classic broad-spectrum antibiotic chloramphenicol, specifically labeled at the dichloroacetyl moiety. This compound is an essential tool for conducting advanced metabolic, pharmacokinetic, and environmental fate studies, providing researchers with a precise tracer to follow the compound's pathway in biological systems. It is primarily required by pharmaceutical R&D laboratories, agrochemical research facilities, and contract research organizations (CROs) engaged in drug development and regulatory safety assessments.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) of chloramphenicol and its analogs in preclinical models.
• Mechanistic Biochemical Research: Investigating the mode of action, including binding to the 50S ribosomal subunit and inhibition of protein synthesis.
• Environmental Fate and Residue Analysis: Studying the degradation, persistence, and bioaccumulation of chloramphenicol in environmental samples.
• Metabolite Identification and Profiling: Aiding in the structural elucidation of novel metabolites formed in in vitro or in vivo systems using advanced analytical techniques like LC-MS.
• Quality Control and Reference Standard: Serving as an internal standard or reference material in quantitative bioanalytical assays for chloramphenicol.
• Veterinary Pharmaceutical Research: Supporting studies on the use and metabolism of chloramphenicol in livestock, where its use is highly regulated.

Basic Information

Product Name	D-Threo-Chloramphenicol, [Dichloroacetyl-1-14C]
CAS No.	138879-88-6
Molecular Formula	C11H12Cl214CN2O5 *
Molecular Weight	~ 323.13 g/mol (unlabeled) *
Synonyms	Chloramphenicol (D-threo isomer), [1'-14C]-Labeled; [Dichloroacetyl-1-14C]-D-threo-Chloramphenicol; (-)-D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]acetamide-1-14C; 14C-Chloramphenicol; Carbon-14 Labeled Chloramphenicol; Antibiotic 14C-CAP; Chloromycetin-14C (labeled); p-Nitrophenylserinol dichloroacetate-14C
EINECS	Contact for details

* Note: Exact molecular weight depends on the specific activity and isotopic enrichment of the 14C label. Contact us for the exact specification of your batch.

Quality Control

Every batch of D-Threo-Chloramphenicol, [Dichloroacetyl-1-14C] is manufactured and analyzed under strict quality protocols to ensure high chemical and radiochemical purity, specific activity, and stability. Our products undergo rigorous quality testing, including HPLC, TLC, and NMR, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing chemical purity, radiochemical purity, specific activity, solvent content, and analytical chromatograms is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures of 2-8°C or as specified on the label. For long-term storage, solutions may be kept at or below -20°C. Always handle and store radioactive materials in accordance with local radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, MS)	Conforms to structure
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Customizable (mCi/mmol)
Solvent (for solutions)	As specified (e.g., Ethanol, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.