Description

Bradykinin, 1-Adamantanecarboxylic Acid-Arg(0)-Hyp(3)-Thi(5,8)-Phe(7)- is a chemically modified peptide analog of the endogenous vasoactive nonapeptide bradykinin. This compound is engineered for enhanced stability and specificity, making it a critical research tool for studying the kallikrein-kinin system, inflammation, and pain pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in cardiovascular, neuropharmacology, and inflammatory disease research.

Application

• Biomedical Research: As a potent and selective ligand for probing bradykinin receptor (B1 and B2) structure, function, and signaling mechanisms.
• Drug Discovery: Serving as a reference standard or a lead compound in the development of novel anti-inflammatory, analgesic, or cardioprotective therapeutics.
• Pharmacological Studies: Investigating vascular permeability, blood pressure regulation, and the role of kinins in inflammatory and neuropathic pain models.
• Biochemical Assay Development: Used in the calibration and validation of high-throughput screening (HTS) assays and competitive binding studies.
• Stability & Metabolism Research: Studying the effects of structural modifications (adamantane, thiopeptide bonds) on peptide stability against enzymatic degradation.

Basic Information

Product Name	Bradykinin, 1-Adamantanecarboxylic Acid-Arg(0)-Hyp(3)-Thi(5,8)-Phe(7)-
CAS No.	138866-14-5
Molecular Formula	C58H86N16O11S2
Molecular Weight	1215.53 g/mol
Synonyms	1-Adamantanecarbonyl-Arg0-Hyp3-[Thi5,8, D-Phe7]-Bradykinin; [Ada0, Hyp3, Thi5,8, D-Phe7]-Bradykinin; B-9972; Adamantaneacetyl-Bradykinin analog; Thiopeptide Bradykinin analog; BK analog B-9972; Bradykinin B1/B2 Receptor Agonist/Antagonist Research Compound
EINECS	Contact for details

Quality Control

Our high-purity peptide products undergo rigorous analytical testing to ensure identity, purity, and consistency for critical research applications. Quality is verified by HPLC, mass spectrometry (MS), and amino acid analysis (AAA). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, supporting compliance with internal quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.