Description

Fmoc-5-Methyl-Dl-Tryptophan CAS NO 138775-52-7 is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for researchers and manufacturers developing complex peptides and peptidomimetics for pharmaceutical and biochemical applications. It is primarily utilized by peptide chemists, R&D laboratories, and fine chemical suppliers focused on producing high-value therapeutic peptides, diagnostic agents, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise construction of peptide chains, particularly where the tryptophan side chain requires protection from harsh coupling conditions.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Biochemical Research: Used to incorporate modified tryptophan residues into peptides to study protein structure, function, and protein-protein interactions.
• Peptidomimetic Development: Enables the creation of non-natural peptide analogs with enhanced stability, bioavailability, or biological activity for drug discovery.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse arrays of peptides for high-throughput screening against biological targets.
• Antibody-Drug Conjugate (ADC) Linker/Payload Synthesis: May be employed in the synthesis of specialized peptide linkers or as part of the cytotoxic payload structure in ADC development.

Basic Information

Product Name	Fmoc-5-Methyl-Dl-Tryptophan
CAS No.	138775-52-7
Molecular Formula	C₂₈H₂₆N₂O₄
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-5-Me-DL-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methyl-DL-tryptophan; 5-Methyl-DL-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-5-methyltryptophan; N-Fmoc-5-methyl-DL-tryptophan; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-methyl-1H-indol-3-yl)propanoic acid; DL-5-Methyltryptophan, N-Fmoc derivative; Fmoc-5-Methyl-Trp-OH
EINECS	Contact for details

Quality Control

Our Fmoc-5-Methyl-Dl-Tryptophan is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and production applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.