Description

Fmoc-1-Methyl-Dl-Tryptophan CAS NO 138775-51-6 is a protected, non-natural amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the unique structural and functional properties of the tryptophan side chain into synthetic peptides and peptidomimetics while providing orthogonal protection for the α-amino group. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, biochemical probes, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of complex peptides containing modified tryptophan residues.
• Pharmaceutical Research: Used in the development of peptide-based drug candidates, hormone analogs, and enzyme inhibitors where side-chain modification is required for stability or activity.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescently labeled peptides or affinity tags for biochemical and cellular studies.
• Peptidomimetic Design: Incorporation into non-natural peptide backbones to study structure-activity relationships and enhance metabolic stability.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Academic & Institutional Research: Fundamental research tool in organic chemistry, medicinal chemistry, and chemical biology departments.

Basic Information

Product Name	Fmoc-1-Methyl-Dl-Tryptophan
CAS No.	138775-51-6
Molecular Formula	C₂₇H₂₄N₂O₄
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-1-Me-DL-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-methyl-DL-tryptophan; 1-Methyl-DL-tryptophan N-fluorenylmethoxycarbonyl derivative; Fmoc-1-Methyltryptophan; N-Fmoc-1-methyltryptophan; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-1-Methyl-Dl-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify the DL-mixture. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements, supporting cGMP development for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.