Description

Fmoc-n-Methyl-D-Phenylalanine CAS NO 138775-05-0 is a high-purity, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the sterically hindered and chiral N-methyl-D-phenylalanine residue into peptide chains, a modification known to enhance metabolic stability and modulate biological activity. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and proteolysis-targeting chimeras (PROTACs).

Application

• Pharmaceutical Peptide Synthesis: A key protected amino acid for the Fmoc-SPPS strategy in creating complex peptide-based drug candidates.
• Peptidomimetic Development: Used to incorporate N-methylated D-amino acids, which improve oral bioavailability and resistance to enzymatic degradation.
• PROTAC & Molecular Glue Research: Serves as a crucial linker or structural component in the design of targeted protein degradation therapeutics.
• Chemical Biology & Proteomics: Employed in the synthesis of peptide probes, substrates, and inhibitors for studying enzyme function and protein-protein interactions.
• Bioconjugation: Acts as a specialized spacer or functional handle in the site-specific modification of biomolecules.
• Academic & Contract Research: A fundamental reagent for universities and CROs engaged in advanced medicinal chemistry and peptide science projects.

Basic Information

Product Name	Fmoc-n-Methyl-D-Phenylalanine
CAS No.	138775-05-0
Molecular Formula	C25H23NO4
Molecular Weight	401.46 g/mol
Synonyms	Fmoc-N-Me-D-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid; Fmoc-N-methyl-D-phenylalanine; Fmoc-D-N-Me-Phe-OH; N-Fmoc-N-methyl-D-phenylalanine; N-α-Fmoc-N-methyl-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-D-Phenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with relevant guidelines for pharmaceutical ingredient sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.