Description

Fmoc-D-Me-Ala-Oh CAS NO 138774-92-2 is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the sterically hindered D-α-methylalanine residue into peptide chains, enabling the creation of novel structures with enhanced metabolic stability and conformational control. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of complex peptides containing D-α-methylalanine.
• Peptidomimetic Drug Discovery: Used to create constrained peptide analogs with improved bioavailability and receptor selectivity for drug candidate development.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Antimicrobial Peptide (AMP) Development: Facilitates the design of novel AMPs with enhanced stability against proteolytic degradation.
• GPCR Ligand Synthesis: Integral for constructing peptide-based ligands targeting G-protein-coupled receptors.
• Custom Peptide Service Providers: A high-value reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-D-Me-Ala-Oh
CAS No.	138774-92-2
Molecular Formula	C19H19NO4
Molecular Weight	325.36 g/mol
Synonyms	Fmoc-D-α-methylalanine; N-(9-Fluorenylmethoxycarbonyl)-D-α-methylalanine; Fmoc-D-α-Me-Ala-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid; Fmoc-D-Ala(α-Me)-OH; N-Fmoc-D-2-aminoisobutyric acid; Fmoc-D-Aib-OH; Fmoc-D-2-methylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Me-Ala-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural verification. We provide Certificates of Analysis (COA) with detailed specifications, ensuring traceability and compliance with research and cGMP-grade material requirements where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% de (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.