Description

Dynein-Associated Protein, 150-Kda CAS NO 138757-12-7 is a high-purity, research-grade protein complex integral to the study of intracellular transport and microtubule-based motility. This product is essential for researchers and developers requiring a reliable and well-characterized component for mechanistic studies in molecular and cellular biology. It is primarily utilized in life science research, pharmaceutical development, and diagnostic assay development, where understanding the role of dynein and its regulatory proteins is critical.

Application

• Biochemical Research: Used as a key reagent in in vitro assays to study the mechanism of cytoplasmic dynein, including motor activity, ATP hydrolysis, and cargo binding.
• Drug Discovery Screening: Serves as a target protein in high-throughput screening platforms to identify potential therapeutic compounds that modulate intracellular transport pathways, relevant for neurological diseases and cancer.
• Cellular Biology Studies: Employed in pull-down assays, co-immunoprecipitation, and protein-protein interaction studies to map the dynein interactome and regulatory networks.
• Diagnostic Development: Acts as a reference standard or antigen in the development of immunoassays and diagnostic kits for conditions linked to dynein dysfunction.
• Academic & Institutional Research: Fundamental tool for laboratories investigating microtubule dynamics, organelle transport, ciliary function, and mitosis.

Basic Information

Product Name	Dynein-Associated Protein, 150-Kda
CAS No.	138757-12-7
Molecular Formula	Contact for details
Molecular Weight	~150 kDa
Synonyms	150 kDa Dynein-Associated Protein; DAP-150; Dynein Activator Protein; Cytoplasmic Dynein 150 kDa Subunit; Microtubule-Associated Protein 150; Dynein Regulatory Complex Component; p150-Glued Associated Protein; Dynactin-associated 150 kDa Protein
EINECS	Contact for details

Quality Control

Our Dynein-Associated Protein, 150-Kda is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to rigorous quality testing, including purity analysis and functional activity assays, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, buffer composition, and activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Purity (SDS-PAGE)	≥ 90%
Protein Concentration	≥ 0.5 mg/mL
Buffer	Specified phosphate or Tris-based buffer
pH	7.0 - 7.5
Identification (Western Blot)	Positive for target protein
Biological Activity (ATPase Assay)	Lot-specific activity provided on COA
Endotoxin Level	< 1.0 EU/µg (for cell culture grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.