Description

2-(2,4-Difluorobenzoyl)-3-(Dimethylamino)Acrylonitrile is a specialized fluorinated acrylonitrile derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and high-performance agrochemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce difluorobenzoyl and activated acrylonitrile motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluorophenyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the creation of fluorescent tags or activity-based probes for studying enzyme mechanisms and cellular processes.
• Fine Chemical Production: Acts as a versatile synthon for constructing complex heterocycles and other architecturally sophisticated molecules in custom synthesis projects.

Basic Information

Product Name	2-(2,4-Difluorobenzoyl)-3-(Dimethylamino)Acrylonitrile
CAS No.	138716-60-6
Molecular Formula	C₁₂H₁₀F₂N₂O
Molecular Weight	236.22 g/mol
Synonyms	3-(Dimethylamino)-2-(2,4-difluorobenzoyl)acrylonitrile; (2,4-Difluorophenyl)[2-cyano-2-(dimethylamino)ethenyl]methanone; 2-Cyano-3-(dimethylamino)-1-(2,4-difluorophenyl)-2-propen-1-one; 2-(2,4-Difluorobenzoyl)-3-(dimethylamino)-2-propenenitrile; Acrylonitrile, 2-(2,4-difluorobenzoyl)-3-(dimethylamino)-; DFB-DMA Acrylonitrile
EINECS	Contact for details

Quality Control

Our 2-(2,4-Difluorobenzoyl)-3-(Dimethylamino)Acrylonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.