Description

Amyloid β-Protein (1-24) CAS NO 138648-77-8 is a synthetic peptide fragment corresponding to the N-terminal region of the human amyloid-beta protein. This high-purity peptide is a critical research tool for studying the molecular mechanisms of Alzheimer's disease and related neurodegenerative disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers for applications in neurobiology, drug discovery, and assay development.

Application

• Biomedical Research: Fundamental studies on amyloid-beta aggregation, toxicity, and structure-function relationships.
• Drug Discovery & Screening: Serving as a key antigen or target in high-throughput screening assays for potential Alzheimer's therapeutics.
• Antibody Production & Characterization: Used as an immunogen to generate and validate antibodies specific to the amyloid-beta protein.
• Diagnostic Assay Development: A critical component in the development and calibration of ELISA and other immunoassays for detecting amyloid-beta peptides.
• Biophysical Studies: Investigation of peptide-membrane interactions and fibril formation kinetics using techniques like spectroscopy and microscopy.
• Quality Control Reference Standard: Acting as a certified reference material for the quality control of related biological products and assays.

Basic Information

Product Name	Amyloid β-Protein (1-24)
CAS No.	138648-77-8
Molecular Formula	C₁₂₉H₁₈₅N₃₅O₄₀S
Molecular Weight	2899.2 g/mol
Synonyms	Amyloid β-Protein (1-24); Aβ (1-24); β-Amyloid (1-24); Amyloid β-Peptide (1-24); DAEFRHDSGYEVHHQKLVFFAEDVG; Amyloid Precursor Protein (672-695); APP (672-695); Alzheimer's Disease Amyloid Peptide (1-24)
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (1-24) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical characterization, including reverse-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by amino acid analysis)
Solubility	Soluble in water or dilute acetic acid
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.