Description

2-Bromo-5-Methoxybenzonitrile is a versatile halogenated aromatic nitrile building block used extensively in advanced organic synthesis. This compound is valued for its dual reactive sites, the bromine and nitrile groups, which enable a range of coupling and functionalization reactions critical for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted benzonitrile or biaryl ether motifs.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and other crop protection agents where its structure serves as a core scaffold.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers due to its electron-withdrawing nitrile group and potential for cross-coupling.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, allowing for the introduction of the methoxy-bromobenzonitrile moiety into larger systems.
• Ligand and Catalyst Development: Utilized as a starting material for synthesizing novel chelating ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a building block for creating tagged molecules and probes used in biochemical and medicinal chemistry research.

Basic Information

Product Name	2-Bromo-5-Methoxybenzonitrile
CAS No.	138642-47-4
Molecular Formula	C8H6BrNO
Molecular Weight	212.05 g/mol
Synonyms	5-Methoxy-2-bromobenzonitrile; 2-Bromo-5-methoxybenzenecarbonitrile; Benzonitrile, 2-bromo-5-methoxy-; 2-Bromo-5-methoxy phenyl cyanide; 2-Bromo-5-methoxy-benzonitrile; 2-Bromo-5-methoxybenzonitrile (CAS 138642-47-4); 2-Bromo-5-methoxybenzonitrile, 97+%
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Methoxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP environments and research requiring high-purity chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.