Description

Losartan N2-Glucuronide is a major, pharmacologically active metabolite of the antihypertensive drug Losartan. This compound is of critical importance in pharmaceutical research and development for studying the metabolic pathways, pharmacokinetics, and overall safety profile of Losartan-based therapies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism studies, bioanalytical method development, and the synthesis of reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of Losartan metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the biotransformation, clearance, and exposure levels of Losartan in preclinical and clinical research.
• Bioanalytical Method Development: Used to develop and validate robust HPLC, LC-MS, or LC-MS/MS methods for accurate metabolite quantification.
• Impurity Profiling: Employed as a known impurity or degradation product to monitor the quality and stability of Losartan drug substances and products.
• Toxicological Research: Aids in assessing the safety and potential side effects associated with Losartan's metabolic pathway.
• Synthetic Intermediate: Can be used in the chemical synthesis of other related metabolites or labeled analogs for advanced research.

Basic Information

Product Name	Losartan N2-Glucuronide
CAS No.	138584-35-7
Molecular Formula	C33H41ClN6O9
Molecular Weight	701.17 g/mol
Synonyms	Losartan carboxylic acid glucuronide; EXP 3174 glucuronide; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, β-D-Glucopyranosiduronic acid; Losartan metabolite EXP 3174 glucuronide; Losartan N2-β-D-Glucuronide; 5-((2'-Carboxybiphenyl-4-yl)methyl)-2-butyl-4-chloro-1-((2''-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)imidazole β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Losartan N2-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality systems support the provision of materials for use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.