Description

Losartan N1-Glucuronide is a major, pharmacologically active metabolite of the antihypertensive drug Losartan. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK). It serves as a vital reference standard for analytical laboratories in pharmaceutical companies, contract research organizations (CROs), and academic institutions requiring precise quantification and metabolic profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of Losartan and its metabolites in biological matrices during bioanalytical studies.
• Drug Metabolism & Pharmacokinetics (DMPK) Research: Essential for studying the metabolic pathways, bioavailability, and elimination profile of Losartan in preclinical and clinical research.
• Analytical Method Development & Validation: Used to develop, calibrate, and validate high-performance liquid chromatography (HPLC), LC-MS/MS, and other analytical methods.
• Impurity Profiling and Control: Acts as a known impurity or metabolite standard for ensuring the quality and safety of Losartan active pharmaceutical ingredient (API) and finished dosage forms.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential drug-drug interactions associated with Losartan therapy.
• Regulatory Submissions: Critical for generating data required for regulatory filings with agencies like the FDA, EMA, and PMDA.

Basic Information

Product Name	Losartan N1-Glucuronide
CAS No.	138584-34-6
Molecular Formula	C33H41ClN6O9
Molecular Weight	701.17 g/mol
Synonyms	Losartan Carboxylic Acid N1-Glucuronide; EXP 3174 N1-Glucuronide; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, β-D-Glucopyranosiduronic Acid Derivative; Losartan Metabolite N1-Glucuronide; Losartan N1-β-D-Glucuronide; E-3174 N1-Glucuronide
EINECS	Contact for details

Quality Control

Our Losartan N1-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.