Description

N,N'-[(1R,2R)-1,2-Diphenyl-1,2-Ethanediyl]Bis[2-(Diphenylphosphino)-Benzamide is a high-value, chiral bisphosphine ligand crucial for enabling highly selective asymmetric catalytic transformations. This compound matters because it provides exceptional stereochemical control in the synthesis of complex pharmaceutical intermediates and fine chemicals. Industrial chemists and R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors need this ligand to achieve superior enantioselectivity and yield in critical hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce single-enantiomer active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Enables the construction of chiral centers in complex drug candidates for therapeutic areas such as oncology and central nervous system disorders.
• Cross-Coupling Reactions: Used in palladium-catalyzed asymmetric cross-coupling to form carbon-carbon and carbon-heteroatom bonds with high stereofidelity.
• Agrochemical Manufacturing: Facilitates the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: Serves as a sophisticated tool for developing new catalytic methodologies and exploring novel reaction pathways in process chemistry.
• Fine Chemical Production: Applied in the synthesis of specialty chemicals, flavors, and fragrances where precise chirality is required.

Basic Information

Product Name	N,N'-[(1R,2R)-1,2-Diphenyl-1,2-Ethanediyl]Bis[2-(Diphenylphosphino)-Benzamide
CAS No.	138517-62-1
Molecular Formula	C66H52N2O2P2
Molecular Weight	967.07 g/mol
Synonyms	(R,R)-DIPAMP-Benzamide Derivative; (1R,2R)-N,N'-Bis[2-(diphenylphosphino)benzoyl]-1,2-diphenyl-1,2-ethanediamine; (R,R)-DACH-Based Bisphosphine Ligand; (R,R)-1,2-Diphenyl-1,2-ethanediamine-N,N'-bis(2-diphenylphosphinobenzamide); (R,R)-DPEN-Bis(Diphenylphosphinobenzamide); 138517-62-1; (R,R)-BDPB; Chiral Diphosphine Ligand 138517-62-1
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by comprehensive analytical techniques including HPLC for chiral purity, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) documenting identity, purity (typically >97%), enantiomeric excess, and residual solvent levels is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (argon or nitrogen) is recommended. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.