Description

(1R,2R)-(+)-1,2-Diaminocyclohexane-N,N'-Bis(2'-Diphenylphosphinobenzoyl) is a high-value, chiral bisphosphine ligand crucial for enabling highly selective catalytic transformations in asymmetric synthesis. Its primary value lies in its ability to form stable complexes with transition metals, directing reactions to produce single enantiomer products with exceptional purity and yield. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing novel active ingredients and high-performance materials.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral intermediates in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling and addition reactions to construct complex chiral carbon frameworks with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for manufacturing enantiomerically pure active pharmaceutical ingredients (APIs) for cardiovascular, CNS, and oncology drugs.
• Agrochemical Production: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Fine Chemical and Fragrance Manufacturing: Enables the production of high-value chiral flavors, fragrances, and specialty chemicals.
• Academic and Industrial R&D: A vital tool for methodology development and exploring new catalytic cycles in academic laboratories and corporate R&D centers.
• Catalyst Screening Libraries: Serves as a benchmark or component in high-throughput screening for discovering new asymmetric catalysts.

Basic Information

Item	Details
Product Name	(1R,2R)-(+)-1,2-Diaminocyclohexane-N,N'-Bis(2'-Diphenylphosphinobenzoyl)
CAS No.	138517-61-0
Molecular Formula	C46H42N2O2P2
Molecular Weight	732.78 g/mol
Synonyms	(R,R)-DACH-Phenyl Trost Ligand; (R,R)-DACH-Phenyl Trost's Ligand; (1R,2R)-1,2-Diaminocyclohexane-N,N'-bis(2-diphenylphosphinobenzoyl); (R,R)-DACH-Phenyl; Trost Ligand (R,R)-DACH-Phenyl; (R,R)-1,2-Diaminocyclohexane-N,N'-bis(2-diphenylphosphinobenzoyl); (+)-1,2-Diaminocyclohexane-N,N'-bis(2-diphenylphosphinobenzoyl) (R,R)-
EINECS	Contact for details

Quality Control

Every batch of our (1R,2R)-(+)-1,2-Diaminocyclohexane-N,N'-Bis(2'-Diphenylphosphinobenzoyl) is produced and tested under strict quality management systems to ensure exceptional purity, enantiomeric excess, and batch-to-batch consistency. Our standard analytical suite includes HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We can support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.