Description

Atrial Natriuretic Factor (1-27) is a bioactive peptide fragment derived from the N-terminal region of the atrial natriuretic peptide (ANP) prohormone. This compound is of significant interest for its role in cardiovascular research, particularly in studying the structure-activity relationships and receptor binding mechanisms of natriuretic peptides. It serves as a critical reference standard and research tool for pharmaceutical developers, academic institutions, and contract research organizations (CROs) focused on hypertension, heart failure, and renal function.

Application

• Biomedical Research: Used as a reference standard in studies investigating the physiological effects and signaling pathways of atrial natriuretic peptides.
• Drug Discovery & Development: Serves as a key intermediate or analytical standard in the development of novel cardiovascular therapeutics targeting natriuretic peptide receptors.
• In Vitro Assays: Employed in receptor binding assays, enzyme-linked immunosorbent assays (ELISAs), and other biochemical tests to quantify ANP activity or assess compound interactions.
• Academic Studies: Utilized in university and institutional labs for fundamental research on blood pressure regulation, sodium homeostasis, and cardiac endocrinology.
• Quality Control: Acts as a high-purity standard for the calibration and validation of analytical methods (e.g., HPLC, MS) used in peptide manufacturing and quality assurance.

Basic Information

Product Name	Atrial Natriuretic Factor (1-27)
CAS No.	138506-90-8
Molecular Formula	C128H205N43O41S2
Molecular Weight	3071.5 g/mol
Synonyms	ANF (1-27); Atrial Natriuretic Peptide (1-27); ANP (1-27); Cardionatrin (1-27); Atriopeptin (1-27); Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23); H-SLRRSSSCFGGRIDRIGAQSGLGCNSPR-OH (Disulfide bridge)
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Factor (1-27) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for laboratory chemicals, and specifications can be tailored to meet the requirements of specific pharmacopeial or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Biological Activity	Assayed by in vitro bioactivity test (available upon request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.