Description

(S)-Fmoc-Phenylalanine-4-Sulfonic Acid is a high-purity, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing sulfonic acid functionality into peptide chains, significantly enhancing solubility and modifying bioactivity. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, used to incorporate sulfonated phenylalanine residues.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates where enhanced water solubility and specific ionic interactions are required.
• Bioconjugation & Probe Development: Creating labeled peptides for diagnostic assays, imaging probes, and targeted drug delivery systems.
• Chemical Biology Studies: Investigating protein-protein interactions and enzyme mechanisms by incorporating this non-natural amino acid into model peptides.
• Material Science: Development of functionalized peptides for surface modification and creation of bio-inspired materials.

Basic Information

Product Name	(S)-Fmoc-Phenylalanine-4-Sulfonic Acid
CAS No.	138472-22-7
Molecular Formula	C24H21NO7S
Molecular Weight	467.49 g/mol
Synonyms	Fmoc-Phe(4-SO3H)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-sulfo-L-phenylalanine; Fmoc-L-phenylalanine-4-sulfonic acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(4-sulfophenyl)propanoic acid; N-α-Fmoc-4-sulfo-L-phenylalanine; Fmoc-Sulfotyrosine analogue; Fmoc-4-Sulfo-L-Phe-OH
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-Phenylalanine-4-Sulfonic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for advanced peptide synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.