Description

(S)-1-(tert-Butoxycarbonyl)-4,4-Dimethylpyrrolidine-2-Carboxylic Acid CAS NO 138423-86-6 is a high-purity, chiral N-Boc protected proline derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality chiral intermediates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and other drug discovery programs.
• Peptide Synthesis: Used as a constrained, sterically hindered proline analog in solid-phase and solution-phase peptide chemistry to influence secondary structure.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Serves as a building block for developing novel, chiral active ingredients with specific biological activity.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and tools to study biological systems and enzyme function.
• Academic & Process R&D: A valuable reagent for methodological development and scaling enantioselective synthetic routes in research laboratories.

Basic Information

Product Name	(S)-1-(tert-Butoxycarbonyl)-4,4-Dimethylpyrrolidine-2-Carboxylic Acid
CAS No.	138423-86-6
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	(S)-1-Boc-4,4-dimethylproline; (S)-1-[(1,1-Dimethylethoxy)carbonyl]-4,4-dimethyl-2-pyrrolidinecarboxylic Acid; (S)-4,4-Dimethyl-1-((tert-butoxy)carbonyl)pyrrolidine-2-carboxylic Acid; (S)-1-(tert-Butoxycarbonyl)-4,4-dimethylproline; (S)-N-Boc-4,4-dimethylproline; Boc-4,4-dimethyl-(S)-proline; (S)-Boc-4,4-Dimethylproline; 4,4-Dimethyl-N-Boc-L-proline
EINECS	Contact for details

Quality Control

Our (S)-1-(tert-Butoxycarbonyl)-4,4-Dimethylpyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and custom synthesis and specific purity grades (e.g., >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.