Description

Arnt Protein CAS NO 138391-32-9 is a high-purity recombinant protein, specifically the Aryl hydrocarbon receptor nuclear translocator (ARNT), a key transcription factor involved in cellular response to hypoxia and xenobiotics. This product is essential for researchers and developers in life sciences, providing a critical reagent for studying gene regulation, signal transduction pathways, and environmental stress responses. It is primarily utilized in biochemical research, pharmaceutical development, and diagnostic assay manufacturing.

Application

• Biochemical Research: Used as a critical component in studies of the hypoxia-inducible factor (HIF) signaling pathway and the aryl hydrocarbon receptor (AhR) pathway.
• Drug Discovery & Development: Serves as a target protein for screening potential therapeutic compounds aimed at modulating cellular responses to low oxygen or toxic compounds.
• Diagnostic Kit Manufacturing: Employed as a calibrated antigen or control protein in the development of immunoassays and ELISA kits for research purposes.
• Cell Signaling Studies: Essential for in vitro experiments investigating dimerization with partner proteins like HIF-1α or AhR and subsequent DNA binding.
• Academic & Institutional Research: A fundamental tool for universities and research institutes exploring molecular biology, toxicology, and cancer biology.
• Biopharmaceutical Production Support: Used in quality control and process development for biologics whose mechanisms involve related pathways.

Basic Information

Product Name	Arnt Protein
CAS No.	138391-32-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Aryl hydrocarbon receptor nuclear translocator; ARNT; HIF-1β; Hypoxia-inducible factor 1-beta; bHLHe2; Class E basic helix-loop-helix protein 2; TANGO; Ah receptor nuclear translocator
EINECS	Contact for details

Quality Control

Our Arnt Protein is produced under stringent conditions to ensure high batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, identity confirmation, and functional activity assays. A Certificate of Analysis (COA) detailing specific results for purity, endotoxin levels, and biological activity is provided with every shipment to guarantee it meets rigorous research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 90%
Identification (Western Blot)	Positive for ARNT
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Confirmed by functional assay (e.g., DNA binding or dimerization)
Protein Concentration	As per COA (typically 0.1 - 1.0 mg/mL)
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.