Description

(S)-2-n-Boc-Amino-1-Pyrrolidin-1-Yl-Propan-1-One CAS NO 138356-92-0 is a high-purity, chiral building block featuring a Boc-protected amino group and a pyrrolidinyl ketone moiety. This compound is critical for the synthesis of complex molecules where stereochemical integrity is paramount, offering researchers and manufacturers a reliable and well-defined starting material. It is primarily utilized in pharmaceutical research and development, particularly in the synthesis of active pharmaceutical ingredients (APIs), peptidomimetics, and other bioactive compounds requiring specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Peptidomimetics & Protease Inhibitors: Serves as a crucial building block for constructing peptide analogs and inhibitors targeting various enzymes.
• Asymmetric Synthesis: Used in stereoselective chemical reactions to introduce the (S)-configured amino acid derivative into target molecules.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs, especially in central nervous system (CNS) and metabolic disease targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale GMP batches.
• Academic Research: Employed in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(S)-2-n-Boc-Amino-1-Pyrrolidin-1-Yl-Propan-1-One
CAS No.	138356-92-0
Molecular Formula	C₁₆H₂₈N₂O₃
Molecular Weight	296.41 g/mol
Synonyms	(S)-1-(2-((tert-Butoxycarbonyl)amino)propanoyl)pyrrolidine; (S)-2-(Boc-amino)-1-(1-pyrrolidinyl)-1-propanone; (S)-N-Boc-Ala-Pyrrolidine; Boc-L-Ala-Pyrrolidine; (S)-2-((tert-Butoxycarbonyl)amino)-1-(pyrrolidin-1-yl)propan-1-one; tert-Butyl (S)-(1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)carbamate; (S)-Boc-Alanine pyrrolidide; L-Boc-Ala-Pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-2-n-Boc-Amino-1-Pyrrolidin-1-Yl-Propan-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.