Description

Endothelin-Converting Enzyme 1 CAS NO 138238-81-0 is a crucial metalloprotease enzyme that plays a pivotal role in the regulation of vascular tone and blood pressure. Its primary function is to catalyze the conversion of the inactive precursor, big endothelin, into the potent vasoconstrictor peptide, endothelin-1. This product is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on cardiovascular disease research, hypertension studies, and the development of novel therapeutic agents targeting the endothelin system.

Application

• Biochemical Research: Used as a critical reagent in enzymatic assays to study the endothelin-converting enzyme pathway and its physiological effects.
• Drug Discovery & Development: Serves as a key target enzyme for high-throughput screening (HTS) to identify and characterize potential inhibitors for cardiovascular and renal diseases.
• Vascular Biology Studies: Employed in in vitro and ex vivo models to investigate mechanisms of vasoconstriction, vascular remodeling, and endothelial dysfunction.
• Academic Research: Utilized in university and institutional labs for fundamental research into hypertension, pulmonary arterial hypertension, and heart failure.
• Diagnostic Kit Development: Acts as a component in the development of enzymatic activity assays and diagnostic kits related to endothelin system dysregulation.

Basic Information

Product Name	Endothelin-Converting Enzyme 1
CAS No.	138238-81-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ECE-1; Endothelin Converting Enzyme 1; ECE1; EC 3.4.24.71; Big Endothelin-Converting Enzyme; Endothelin-Converting Enzyme (ECE); Kell Blood Group Protein; Metalloprotease ECE-1; Membrane Metalloprotease; Endothelin-Converting Enzyme Type 1
EINECS	Contact for details

Quality Control

Our Endothelin-Converting Enzyme 1 is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot undergoes rigorous analytical testing, including activity assays and purity assessments, to meet the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA), detailing specific activity, purity, and storage buffer information, is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent moisture absorption. For short-term use, aliquots may be stored at 2-8°C. Avoid repeated freeze-thaw cycles to maintain optimal enzymatic activity.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	≥ X units/mg protein (Contact for details)
Purity (SDS-PAGE)	≥ 90%
Protein Concentration	As per COA
Buffer Composition	Tris, NaCl, Glycerol, etc. (Contact for details)
Endotoxin Level	< 1.0 EU/μg (for cell culture grades)
Storage Buffer pH	7.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.