Description

6-Chloro-1H-Indol-3-Yl β-D-Glucopyranosiduronic Acid is a specialized biochemical derivative of indole, conjugated with glucuronic acid. This compound is of significant value in pharmaceutical research and development, particularly as a reference standard or metabolite in drug metabolism and pharmacokinetic (DMPK) studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in analytical chemistry, toxicology, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods for quantifying drug metabolites.
• Drug Metabolism Studies: Serves as a key metabolite or analog in investigating the biotransformation pathways of indole-based pharmaceuticals.
• Enzymology Research: Applied in studies of UDP-glucuronosyltransferase (UGT) enzyme activity and glucuronidation kinetics.
• Analytical Method Development: Essential for developing and validating HPLC, LC-MS, and other chromatographic assays in bioanalytical laboratories.
• Toxicology and Safety Assessment: Employed as a marker in studies assessing the excretion and clearance profiles of related compounds.
• Biochemical Reagent: Used in research focused on phase II drug conjugation and detoxification processes.

Basic Information

Product Name	6-Chloro-1H-Indol-3-Yl β-D-Glucopyranosiduronic Acid
CAS No.	138182-19-1
Molecular Formula	C14H14ClNO7
Molecular Weight	343.72 g/mol
Synonyms	6-Chloroindol-3-yl β-D-glucopyranosiduronic acid; 6-Chloro-3-indolyl β-D-glucuronide; 6-Chloroindoxyl glucuronide; 6-Chloro-1H-indol-3-yl β-D-glucuronide; 3-(β-D-Glucopyranosiduronic acid)-6-chloroindole; 6-Chloro-3-indolyl-β-D-glucuronic acid; 6-Cl-I-3-Gluc; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 6-Chloro-1H-Indol-3-Yl β-D-Glucopyranosiduronic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.