Description

1-Cbz-4-Methylene-Piperidine is a versatile and high-purity chemical building block, primarily used in advanced organic synthesis. Its value lies in its role as a key protected intermediate for constructing complex nitrogen-containing heterocycles, which are foundational to modern pharmaceutical discovery. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound library generation.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of piperidine-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Protecting Group Chemistry: The Cbz (carboxybenzyl) group serves as a standard amine protector in multi-step synthetic routes, enabling selective reactions.
• Medicinal Chemistry Research: Used in the design and construction of compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Serves as an intermediate in the development of new pesticides and herbicides that incorporate the piperidine scaffold.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, catalysts, and ligands for asymmetric synthesis.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-Cbz-4-Methylene-Piperidine
CAS No.	138163-12-9
Molecular Formula	C14H17NO2
Molecular Weight	231.29 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-methylenepiperidine; 4-Methylene-1-piperidinecarboxylic Acid Benzyl Ester; 1-Carbobenzoxy-4-methylenepiperidine; N-Cbz-4-Methylenepiperidine; Benzyl 4-methylenepiperidine-1-carboxylate; 1-(Benzyloxycarbonyl)-4-methylenepiperidine; Piperidine, 4-methylene-, 1-carbamate, N-benzyl-
EINECS	Contact for details

Quality Control

Our 1-Cbz-4-Methylene-Piperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.