Description

Fmoc-Cys(Me)-Oh is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound, with CAS number 138021-87-1, serves as a critical building block for the controlled introduction of S-methylated cysteine residues into peptide chains. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research laboratories developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of custom peptides on resin.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs where the unique properties of S-methyl cysteine are required for stability, activity, or structural conformation.
• Bioconjugation and Protein Engineering: Enables site-specific modification of peptides and proteins, facilitating the creation of labeled or functionalized biomolecules for diagnostics and studies.
• Peptidomimetic Research: Acts as a key intermediate in the design and synthesis of non-natural peptide analogs with enhanced pharmacological properties.
• Chemical Biology Probes: Incorporated into peptides used as tools to study enzyme mechanisms, protein-protein interactions, and cellular pathways.
• Material Science: Potential use in the synthesis of peptide-based polymers and advanced biomaterials with specific functional groups.

Basic Information

Product Name	Fmoc-Cys(Me)-Oh
CAS No.	138021-87-1
Molecular Formula	C₂₀H₂₁NO₄S
Molecular Weight	371.45 g/mol
Synonyms	Fmoc-S-methyl-L-cysteine; N-(9-Fluorenylmethoxycarbonyl)-S-methyl-L-cysteine; Fmoc-Cys(Me)-OH; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(methylsulfanyl)propanoic acid; Fmoc-L-Cys(Me)-OH; N-Fmoc-S-methylcysteine; Fmoc-Cysteine(S-methyl)-OH; Nα-Fmoc-S-methyl-L-cysteine
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Me)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.