Description

Benzeneacetonitrile, 3-Fluoro-α-Hydroxy-, (R)- (9Ci) is a chiral, fluorinated synthetic intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of enantiomerically pure pharmaceuticals and agrochemicals, where the specific (R)- configuration and fluorine substitution are critical for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Research: Used in the development of novel, enantiopure herbicides and pesticides where the fluorine atom enhances metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile precursor for the construction of complex, non-racemic molecules in academic and industrial research laboratories.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for stereoselective transformations.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) in medicinal chemistry due to its defined stereochemistry and fluorine substituent.

Basic Information

Item	Detail
Product Name	Benzeneacetonitrile, 3-Fluoro-α-Hydroxy-, (R)- (9Ci)
CAS No.	137993-38-5
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	(R)-3-Fluoro-mandelonitrile; (R)-α-Hydroxy-3-fluorobenzeneacetonitrile; (R)-2-Fluoro-2-(3-fluorophenyl)acetonitrile (tautomer); 3-Fluoro-(R)-mandelonitrile; (R)-3-Fluoromandelonitrile; (R)-2-(3-Fluorophenyl)-2-hydroxyacetonitrile; (R)-3-Fluorobenzaldehyde cyanohydrin
EINECS	Contact for details

Quality Control

Our Benzeneacetonitrile, 3-Fluoro-α-Hydroxy-, (R)- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.