Description

Doxylamine β-D-Glucuronide CAS NO 137908-79-3 is a high-purity conjugated metabolite of the antihistamine doxylamine, formed via glucuronidation. This compound is of critical importance as a certified reference standard for analytical and bioanalytical applications, ensuring accurate quantification and method validation. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers for pharmacokinetic studies, drug metabolism research, and clinical toxicology testing.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration of analytical instruments in drug development.
• Metabolite Identification & Quantification: Essential for in vitro and in vivo studies to identify and measure doxylamine glucuronide levels in biological matrices.
• Bioanalytical Method Development & Validation (BMV): Used to develop, optimize, and validate LC-MS/MS, HPLC, and other chromatographic methods.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Serves as a key analyte for understanding the absorption, distribution, metabolism, and excretion (ADME) profile of doxylamine.
• Clinical Toxicology & Forensic Analysis: Employed as a calibrant or control in assays designed to detect and confirm doxylamine and its metabolites in human samples.
• Quality Control in Manufacturing: Used to ensure the consistency and purity of active pharmaceutical ingredients (APIs) and related substances.

Basic Information

Product Name	Doxylamine β-D-Glucuronide
CAS No.	137908-79-3
Molecular Formula	C21H29ClN2O7
Molecular Weight	456.92 g/mol
Synonyms	Doxylamine Glucuronide; Doxylamine β-D-Glucopyranosiduronic Acid; N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine Glucuronide; Doxylamine O-β-D-Glucuronide; Doxylamine Metabolite; Doxylamine-β-D-Glucuronide; Pyridoxamine Glucuronide (related); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Doxylamine β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for reference materials. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.