Description

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a potent and selective cyclic RGD pentapeptide that functions as a high-affinity antagonist for integrin receptors, particularly αvβ3 and αvβ5. This compound is crucial for inhibiting cell adhesion and signaling pathways mediated by these integrins, making it an essential research tool for studying angiogenesis, tumor metastasis, and bone resorption. It is primarily needed by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, biochemical assay development, and as a reference standard.

Application

• Angiogenesis Research: Used to study and inhibit the formation of new blood vessels, relevant in cancer and ophthalmology research.
• Cancer Metastasis Studies: Employed as a tool compound to investigate tumor cell migration, invasion, and adhesion processes.
• Bone Biology & Osteoporosis Research: Applied in studies of osteoclast function and bone resorption mechanisms.
• Integrin Receptor Antagonism: Serves as a selective antagonist to characterize the function of αvβ3 and αvβ5 integrins in various cell types.
• Drug Discovery & Development: Acts as a lead compound or reference standard in the development of novel anti-cancer and anti-angiogenic therapeutics.
• Biomaterial & Tissue Engineering: Used to functionalize surfaces or materials to modulate cell adhesion and growth for regenerative medicine applications.

Basic Information

Product Name	Cyclo(Arg-Gly-Asp-D-Phe-Val)
CAS No.	137813-35-5
Molecular Formula	C27H41N9O7
Molecular Weight	603.68 g/mol
Synonyms	c(RGDfV); Cyclo(Arg-Gly-Asp-D-Phe-Val); Cyclo(RGDfV); Cilengitide precursor; cRGDfV pentapeptide; Integrin αvβ3 antagonist (cyclic RGD); Cyclo(-Arg-Gly-Asp-D-Phe-Val-); L-Arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valine cyclic (1→4)-peptide
EINECS	Contact for details

Quality Control

Our Cyclo(Arg-Gly-Asp-D-Phe-Val) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by MS and NMR, to ensure it meets high-grade research specifications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.