Description

(S)-(+)-(Diphenylphosphino)-2'-Isopropoxy-1,1'-Binaphthyl is a highly valuable chiral monophosphine ligand, a key component in asymmetric catalysis. Its precise stereochemistry and electron-donating properties are critical for achieving high enantioselectivity and yield in transition metal-catalyzed reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require advanced, enantiomerically pure intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral pharmaceutical building blocks.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high stereocontrol, such as Suzuki-Miyaura and Buchwald-Hartwig aminations.
• Pharmaceutical Intermediate Synthesis: Enables the production of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Fine Chemical and Flavor/Fragrance Production: Applied in the synthesis of complex chiral molecules for high-value specialty chemicals, flavors, and aromas.
• Academic and Process Chemistry Research: A fundamental tool for developing new catalytic methodologies and optimizing synthetic routes in R&D laboratories.

Basic Information

Product Name	(S)-(+)-(Diphenylphosphino)-2'-Isopropoxy-1,1'-Binaphthyl
CAS No.	137769-30-3
Molecular Formula	C35H29O1P1
Molecular Weight	496.58 g/mol
Synonyms	(S)-2'-Isopropoxy-2-(diphenylphosphino)-1,1'-binaphthyl; (S)-(+)-2-(Diphenylphosphino)-2'-isopropoxy-1,1'-binaphthyl; (S)-iPr-BINAP(O); (S)-2'-Isopropoxy-BINAP; (S)-2-(Diphenylphosphino)-2'-(1-methylethoxy)-1,1'-binaphthalene; LICAND (S)-iPr-BINAP(O); (S)-BINAP derivative with 2'-isopropoxy substituent
EINECS	Contact for details

Quality Control

Our (S)-(+)-(Diphenylphosphino)-2'-Isopropoxy-1,1'-Binaphthyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, 31P NMR, and 1H NMR, to ensure high chemical and enantiomeric purity suitable for sensitive catalytic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, the container should be flushed with an inert gas (argon or nitrogen) and kept at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep the container tightly sealed in a dry, cool, and well-ventilated place. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.