Description

cis-Atovaquone is a high-purity, synthetic naphthoquinone derivative, specifically the cis-isomer of the antiprotozoal agent atovaquone. This compound is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) valued for its potent and selective activity against specific pathogens. It is primarily required by manufacturers in the pharmaceutical and life sciences industries for the development and production of advanced therapeutic formulations.

Application

• Primary Active Pharmaceutical Ingredient (API) in antiparasitic and antimicrobial medications.
• Key intermediate in the synthesis of complex pharmaceutical compounds targeting Pneumocystis jirovecii pneumonia (PCP) and malaria.
• Research and development of novel therapeutic agents for protozoal infections.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical research tool for studying mitochondrial electron transport inhibition.
• Formulation studies for improving the bioavailability of poorly soluble drug compounds.

Basic Information

Product Name	cis-Atovaquone
CAS No.	137732-39-9
Molecular Formula	C22H19ClO3
Molecular Weight	366.84 g/mol
Synonyms	trans-Atovaquone Isomer; (3S,4R)-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione; 566C80 (cis-isomer); Atovaquone (cis-); cis-2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone; BW566C80 (cis-isomer)
EINECS	Contact for details

Quality Control

Our cis-Atovaquone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing purity, identity, and related substances are provided to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.