Description

ω-Conotoxin Svib is a highly selective and potent peptide neurotoxin derived from the venom of cone snails. This compound is a crucial research tool for studying N-type voltage-gated calcium channels (Cav2.2) in neuronal signaling and pain pathways. It is primarily utilized by pharmaceutical researchers and neuroscientists in academic, biotech, and R&D settings for electrophysiology studies, receptor characterization, and the development of novel analgesic therapeutics.

Application

• Neuroscience Research: A selective blocker for investigating the function and pharmacology of N-type (Cav2.2) calcium channels in synaptic transmission.
• Pain Pathway Analysis: Used in preclinical studies to elucidate the role of specific calcium channels in nociception and chronic pain models.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening assays for novel non-opioid analgesic candidates.
• Electrophysiology: Essential for patch-clamp experiments to characterize ion channel currents and modulation in neuronal cells.
• Biochemical Assays: Employed in binding studies and competitive inhibition experiments to study receptor-ligand interactions.
• Cellular Signaling Studies: Used to dissect calcium-dependent signaling cascades and neurotransmitter release mechanisms.

Basic Information

Product Name	ω-Conotoxin Svib
CAS No.	137706-83-3
Molecular Formula	C102H172N36O32S6
Molecular Weight	2639.1 g/mol
Synonyms	ω-Conotoxin SVIB; Conotoxin SVIB; ω-Conotoxin SVIB; SNX-325; ω-CTx-SVIB; GVIA-like conotoxin; N-type calcium channel blocker ω-conotoxin; Conus striatus toxin SVIB
EINECS	Contact for details

Quality Control

Our ω-Conotoxin Svib is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is subjected to comprehensive analytical testing, including purity verification by HPLC and mass spectrometry. Certificates of Analysis (COA) detailing purity, peptide content, and bioactivity data are provided to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in aqueous buffers
Biological Activity (IC50)	Specification available upon request

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.