Description

Erk2 CAS NO 137632-08-7 is a potent and selective small-molecule inhibitor of Extracellular signal-Regulated Kinase 2, a key enzyme in the MAPK/ERK signaling pathway. This compound is a critical research tool for studying cellular processes such as proliferation, differentiation, and survival, with significant implications for understanding disease mechanisms. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, neurology, and metabolic disorder research.

Application

• Biochemical Research: Used as a selective inhibitor to elucidate the specific roles of ERK2 in the MAPK signaling cascade and its downstream effects.
• Cell Biology Studies: Employed in in vitro cell culture models to investigate the impact of ERK2 inhibition on cell cycle progression, apoptosis, and gene expression.
• Target Validation: Serves as a pharmacological tool to validate ERK2 as a therapeutic target in various disease models, including cancer and inflammatory conditions.
• High-Throughput Screening (HTS): Acts as a reference compound or positive control in assay development and screening campaigns for novel kinase inhibitors.
• Mechanism of Action (MoA) Studies: Applied in preclinical research to understand drug resistance mechanisms and to explore combination therapy strategies.

Basic Information

Product Name	Erk2
CAS No.	137632-08-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ERK2 Inhibitor; Extracellular signal-regulated kinase 2 inhibitor; MAPK1 Inhibitor; Mitogen-activated protein kinase 1 inhibitor; 137632-08-7; (Compound) Erk2; p42 MAPK Inhibitor
EINECS	Contact for details

Quality Control

Our Erk2 is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and identity confirmation. A detailed Certificate of Analysis (COA), providing full specifications and analytical data, is supplied with every shipment to support your compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. Store in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.