Description

Toxic Shock Syndrome Toxin-1 (58-78) CAS NO 137593-46-5 is a defined synthetic peptide fragment corresponding to residues 58-78 of the Staphylococcal enterotoxin B (SEB) superantigen, also known as Toxic Shock Syndrome Toxin-1 (TSST-1). This high-purity reference standard is critical for immunological research and diagnostic assay development. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on studying superantigen-mediated immune responses, toxic shock syndrome pathology, and developing specific detection kits.

Application

• Immunological Research: Used as a defined antigen to study T-cell activation, cytokine storms, and the molecular mechanisms of superantigen activity associated with Toxic Shock Syndrome.
• Diagnostic Development: Serves as a critical standard and coating antigen in the development and calibration of ELISA, lateral flow assays, and other immunoassays for TSST-1 detection.
• Antibody Production & Screening: Employed as an immunogen for generating monoclonal or polyclonal antibodies with specificity for the TSST-1 epitope region.
• Vaccine Research: Investigated as a potential component or target in vaccine development strategies against Staphylococcus aureus infections.
• Quality Control Reference: Acts as a purity and identity reference standard for in-house quality control of related biological products and reagents.
• Biochemical Studies: Utilized in structural biology and binding studies to understand protein-protein interactions between superantigens and MHC class II molecules or T-cell receptors.

Basic Information

Product Name	Toxic Shock Syndrome Toxin-1 (58-78)
CAS No.	137593-46-5
Molecular Formula	C99H158N30O31S
Molecular Weight	2312.6 g/mol
Synonyms	TSST-1 (58-78); Toxic Shock Syndrome Toxin 1 Fragment 58-78; Staphylococcal Enterotoxin F Fragment (58-78); SEB Superantigen Peptide (58-78); TSS Toxin-1 Peptide; LQQIANDNQRVKQIIKDIKQ; H-Lys-Gln-Gln-Ile-Ala-Asn-Asp-Asn-Gln-Arg-Val-Lys-Gln-Ile-Ile-Lys-Asp-Ile-Lys-Gln-OH
EINECS	Contact for details

Quality Control

Our Toxic Shock Syndrome Toxin-1 (58-78) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Each lot is characterized by Mass Spectrometry (MS) and HPLC, with purity typically exceeding 95%. Certificates of Analysis (COA) detailing purity, identity, and peptide content are provided and available upon request, supporting compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Sequence	LQQIANDNQRVKQIIKDIKQ
Single Peak on HPLC	Pass
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.