Description

L-Isovaline, 3-Methyl-n-[(Phenylmethoxy)Carbonyl]- is a non-proteinogenic amino acid derivative of significant interest in advanced chemical synthesis and pharmaceutical research. Its unique structure, featuring a chiral center and a Cbz-protecting group, makes it a valuable chiral building block for the development of novel bioactive compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to develop peptides, peptidomimetics, and other complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics and enzyme inhibitors.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis for creating custom sequences and peptidomimetics.
• Agrochemical Research: Used in the synthesis of novel chiral compounds with potential herbicidal or insecticidal activity.
• Biochemical Research: Employed as a standard or reagent in metabolic studies and research on amino acid transporters and receptors.
• Material Science: A potential monomer or precursor for synthesizing specialized polymers with unique chiral properties.
• Asymmetric Catalysis: Can be utilized as a ligand precursor or chiral auxiliary in asymmetric synthesis to induce stereoselectivity.

Basic Information

Product Name	L-Isovaline, 3-Methyl-n-[(Phenylmethoxy)Carbonyl]-
CAS No.	137584-40-8
Molecular Formula	C13H17NO4
Molecular Weight	251.28 g/mol
Synonyms	(S)-2-Amino-2-methylbutanoic acid N-benzyloxycarbonyl derivative; N-Cbz-L-isovaline; N-[(Benzyloxy)carbonyl]-L-isovaline; (S)-2-[[(Benzyloxy)carbonyl]amino]-2-methylbutanoic acid; Z-L-Iva-OH; L-Isovaline-Cbz; Benzyl N-[(2S)-1-hydroxy-2-methyl-1-oxobutan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our L-Isovaline, 3-Methyl-n-[(Phenylmethoxy)Carbonyl]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.