Description

Chloroac-D-Phe-Oh CAS NO 137503-97-0 is a high-purity, non-natural amino acid derivative featuring a chloroacetyl group. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis industries for developing novel active pharmaceutical ingredients (APIs) and biochemical tools.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used as a protected or activated amino acid derivative in solid-phase and solution-phase peptide chain assembly.
• Bioconjugation & Linker Chemistry: The chloroacetyl group serves as a reactive handle for attaching peptides to carriers, labels, or solid supports.
• Chemical Biology Research: Employed in the development of enzyme substrates, activity-based probes, and molecular tools for studying biological processes.
• API Development: Integral to the research and scale-up phases of new therapeutic candidates, particularly in oncology and metabolic disease.
• Chiral Auxiliary & Catalyst Synthesis: Utilized in the preparation of chiral ligands and catalysts for asymmetric synthesis.

Basic Information

Product Name	Chloroac-D-Phe-Oh
CAS No.	137503-97-0
Molecular Formula	C11H12ClNO3
Molecular Weight	241.67 g/mol
Synonyms	N-Chloroacetyl-D-phenylalanine; D-N-Chloroacetylphenylalanine; (R)-2-(2-Chloroacetamido)-3-phenylpropanoic acid; Chloroacetyl-D-phenylalanine; D-Phenylalanine, N-chloroacetyl-; Chloroacetyl-D-Phe-OH; N-Chloroacetyl-D-Phe; N-(Chloroacetyl)-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Chloroac-D-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.