Description

Midkine CAS NO 137497-38-2 is a heparin-binding growth factor and cytokine that plays a crucial role in cell proliferation, migration, and angiogenesis. Its significance lies in its involvement in various physiological and pathological processes, making it a key target for biomedical research and therapeutic development. This product is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, neurobiology, tissue repair, and diagnostic biomarker discovery.

Application

• Biomedical Research: Fundamental studies on cell signaling, development, and disease mechanisms.
• Therapeutic Development: Target validation and screening for drug candidates in cancer, neurodegenerative diseases, and inflammatory conditions.
• Diagnostic Reagents: Used as a key component or target in immunoassays and diagnostic kits for conditions like cancer and cardiovascular disease.
• Cell Culture & Tissue Engineering: Acts as a growth supplement to promote neurite outgrowth, cell survival, and tissue regeneration in specialized media.
• Antibody Production: Serves as a critical antigen for generating and testing specific monoclonal and polyclonal antibodies.
• Biomarker Studies: Investigation of Midkine levels as a prognostic or diagnostic marker in various clinical samples.

Basic Information

Product Name	Midkine
CAS No.	137497-38-2
Molecular Formula	C690H1094N186O203S10
Molecular Weight	Approx. 15.3 kDa
Synonyms	Midkine; MK; Neurite growth-promoting factor 2; NEGF2; Amphiregulin-associated protein; ARAP; Heparin-binding neurite-promoting factor; Heparin-binding growth-associated molecule; HB-GAM
EINECS	Contact for details

Quality Control

Our Midkine is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for critical research and development applications. Each batch is subjected to a comprehensive battery of analytical tests, including HPLC for purity, mass spectrometry for identity confirmation, and bioactivity assays (e.g., neurite outgrowth promotion). A detailed Certificate of Analysis (COA) documenting identity, purity, potency, endotoxin levels, and sterility (where applicable) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or desiccated conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Biological Activity	Determined by cell-based assay
Endotoxin Level	< 1.0 EU/µg
Protein Content	Determined by UV absorbance
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.