Description

Cyclophilin B is a peptidyl-prolyl cis-trans isomerase (PPIase) enzyme belonging to the immunophilin family, playing a crucial role in protein folding and cellular signaling. Its significance lies in its function as a key molecular chaperone and its specific interaction with immunosuppressive drugs, making it a vital target for research and therapeutic development. This protein is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors, particularly for studying immunology, neurobiology, and developing novel therapeutics.

Application

• Drug Discovery & Pharmaceutical Research: Critical target for developing immunosuppressive agents and studying drug-protein interactions (e.g., with Cyclosporin A).
• Biochemical & Enzymology Studies: Used as a standard or reagent in assays to measure PPIase (rotamase) activity and enzyme kinetics.
• Cell Signaling & Immunology Research: Employed in studies investigating T-cell activation, inflammatory responses, and intracellular signaling pathways.
• Protein Folding & Chaperone Research: Serves as a model protein to study protein folding mechanisms, stability, and chaperone-assisted refolding.
• Diagnostic Development: Potential use as a component or antigen in developing diagnostic kits for autoimmune or inflammatory conditions.
• Neuroscience Research: Investigated for its role in neuroprotection, neurodegenerative diseases, and neural regeneration.

Basic Information

Product Name	Cyclophilin B
CAS No.	137497-17-7
Molecular Formula	Contact for details
Molecular Weight	~21-24 kDa (monomer)
Synonyms	Peptidyl-prolyl cis-trans isomerase B; PPIB; Rotamase B; Cyclophilin-like protein hCyPB; SCYLP; Cyp-B; PPIase B; 21 kDa cyclophilin; hCyp-21
EINECS	Contact for details

Quality Control

Our Cyclophilin B is produced under stringent conditions to ensure high purity and biological activity, suitable for critical research applications. Each batch undergoes rigorous quality testing, including analysis for purity, identity, and enzymatic activity. Certificates of Analysis (COA) detailing specific test results are available upon request, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (SDS-PAGE)	Single band at ~21-24 kDa
Purity (HPLC)	≥ 95%
Protein Content (Bradford/BCA)	≥ 90%
Specific Activity (PPIase Assay)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.