Description

2-Hydroxyglutaryl-5-Coenzyme A is a specialized biochemical intermediate of significant importance in metabolic research and biosynthesis. This compound plays a crucial role in the study of enzymatic pathways, particularly those involving coenzyme A-dependent transformations. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in advanced metabolic engineering, enzyme mechanism studies, and the development of novel therapeutic agents. Its availability in high purity is essential for ensuring the accuracy and reproducibility of sensitive biochemical assays.

Application

• Biochemical Research: Critical substrate for studying the mechanisms of specific acyl-CoA dehydrogenases and related enzymes in metabolic pathways.
• Pharmaceutical Development: Used as a reference standard or intermediate in the research and development of drugs targeting metabolic disorders.
• Enzymology Studies: Serves as a key reagent for investigating enzyme kinetics, inhibition, and specificity within the CoA-dependent enzyme family.
• Metabolic Engineering: Employed in synthetic biology and pathway optimization for the microbial production of valuable chemicals and biofuels.
• Diagnostic Reagent Manufacturing: Potential use as a component in enzymatic assay kits for clinical diagnostics and research.
• Academic Research: Fundamental tool in university and institutional labs for exploring novel biochemical reactions and pathways.

Basic Information

Product Name	2-Hydroxyglutaryl-5-Coenzyme A
CAS No.	137374-53-9
Molecular Formula	C₂₆H₄₂N₇O₁₉P₃S
Molecular Weight	869.65 g/mol
Synonyms	2-Hydroxyglutaryl-CoA; 2-Hydroxyglutaryl Coenzyme A; (2R)-2-Hydroxyglutaryl-CoA; 2-Hydroxyglutaroyl-coenzyme A; 2-Hydroxyglutaroyl-CoA; α-Hydroxyglutaroyl-CoA; CoA-2-hydroxyglutarate; 5'-O-[N-(2-Hydroxyglutaroyl)sulfanoyl]adenosine 2',3'-cyclic phosphate
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxyglutaryl-5-Coenzyme A is manufactured and analyzed under strict quality control protocols to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Assay dependent; contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.