Description

Protamine P4 is a highly purified, low molecular weight polypeptide derived from protamine, a naturally occurring cationic protein. This compound is valued for its strong binding affinity to heparin and other polyanions, making it a critical agent for neutralizing anticoagulant activity. It is primarily utilized in the biopharmaceutical and life science research sectors for applications requiring precise control of coagulation processes. Our product, Protamine P4 CAS NO 137368-49-1, is manufactured under stringent conditions to ensure consistent quality and performance for demanding industrial and research needs.

Application

• Heparin Neutralization: Primary agent for reversing the anticoagulant effects of heparin in bioprocessing and pharmaceutical manufacturing.
• Biopharmaceutical Purification: Used in downstream processing to precipitate and remove nucleic acid contaminants and other polyanionic impurities.
• Drug Formulation: Serves as a complexing agent or stabilizer in controlled-release drug delivery systems and protein formulations.
• Cell Culture & Research: Employed in laboratory research to study cell membrane interactions, protein binding, and coagulation pathways.
• Diagnostic Reagents: A key component in the formulation of certain in-vitro diagnostic test kits and assays.
• Tissue Engineering: Investigated for use in scaffolds and matrices due to its biocompatibility and binding properties.

Basic Information

Product Name	Protamine P4
CAS No.	137368-49-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Protamine Fragment P4; Protamine P-4; Protamine Peptide P4; Low Molecular Weight Protamine; LMWP P4; Heparin-binding peptide P4; Salmine Fragment P4
EINECS	Contact for details

Quality Control

Our Protamine P4 is produced in compliance with current Good Manufacturing Practices (cGMP) principles to ensure the highest standards of purity and consistency. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and biological activity assays. A comprehensive Certificate of Analysis (COA) documenting identity, purity, potency, and other critical quality attributes is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Potency (Heparin Neutralization)	Conforms to in-house biological standard
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.