Description

Mastoparan B CAS NO 137354-65-5 is a bioactive peptide toxin, specifically a tetradecapeptide, originally isolated from wasp venom. This compound is of significant interest due to its potent activity as a G-protein activator and mast cell degranulator, making it a valuable research tool in cell signaling and immunology studies. It is primarily utilized by researchers and pharmaceutical developers in the fields of biochemistry, pharmacology, and neuroscience for investigating G-protein coupled receptor (GPCR) pathways, calcium signaling, and inflammatory responses.

Application

• Biochemical Research: Used as a direct activator of heterotrimeric G proteins (Gi/Go) to study downstream signaling cascades in cell-free systems and intact cells.
• Immunology Studies: Employed to induce mast cell degranulation for research on allergic responses, histamine release, and anaphylaxis mechanisms.
• Neuroscience Research: Applied in studies of neurotransmitter release and synaptic transmission due to its ability to modulate ion channels and exocytosis.
• Drug Discovery: Serves as a reference compound and pharmacological tool for screening and validating new therapeutics targeting GPCRs and inflammatory pathways.
• Cell Biology: Utilized to probe intracellular calcium mobilization and phospholipase C activation in various cell types.
• Toxin Research: Studied for its structure-activity relationships (SAR) to understand peptide toxin function and design novel bioactive peptides.

Basic Information

Product Name	Mastoparan B
CAS No.	137354-65-5
Molecular Formula	C71H115N21O19
Molecular Weight	1506.8 g/mol
Synonyms	Mastoparan B (Vespula lewisii); INWKGIKAMGKIIKV-NH2; Mastoparan-B; Mastoparan B Peptide; H-INWKGIKAMGKIIKV-NH2; Tetradecapeptide Mastoparan B; G-protein activator peptide; Vespula lewisii mastoparan B
EINECS	Contact for details

Quality Control

Our Mastoparan B is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and Mass Spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder under desiccant. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Conforms to theoretical composition
Solubility	Soluble in water, DMSO, aqueous acetic acid
Single Impurity (HPLC)	≤ 1.0%
Biological Activity	Tested for mast cell degranulation / G-protein activation (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.