Description

tert-Butyl Tetraisopropylphosphorodiamidite is a high-purity organophosphorus compound widely used as a key phosphitylating reagent in oligonucleotide synthesis. This compound is critical for the efficient and selective introduction of phosphorus groups during the solid-phase assembly of DNA and RNA strands. It is an essential raw material for manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors, particularly those focused on antisense oligonucleotides, siRNA, and other therapeutic nucleic acids.

Application

• Phosphoramidite Reagent in Oligonucleotide Synthesis: Serves as a crucial building block in automated solid-phase synthesis for creating DNA and RNA sequences.
• Therapeutic Nucleic Acid Production: Used in the manufacture of advanced therapeutics, including antisense oligonucleotides, siRNA (small interfering RNA), and aptamers.
• Research & Diagnostic Probes: Enables the production of labeled probes and primers for PCR, sequencing, and genetic testing applications.
• Process Development: Employed in R&D laboratories for developing and scaling up novel oligonucleotide-based drugs and tools.
• Contract Manufacturing: A vital raw material for CDMOs (Contract Development and Manufacturing Organizations) specializing in nucleic acid APIs.
• High-Value Chemical Intermediate: Acts as a specialized intermediate in the synthesis of complex organophosphorus compounds for catalytic and material science applications.

Basic Information

Product Name	tert-Butyl Tetraisopropylphosphorodiamidite
CAS No.	137348-88-0
Molecular Formula	C16H37N2O2P
Molecular Weight	320.45 g/mol
Synonyms	tert-Butyl N,N,N',N'-Tetraisopropylphosphorodiamidite; tert-Butyl Tetraisopropylphosphordiamidite; Phosphorodiamidous acid, P-(1,1-dimethylethyl)-, N,N,N',N'-tetrakis(1-methylethyl) ester; t-Bu-Tetraisopropylphosphorodiamidite; tBu-TIPA; tert-Butylbis(diisopropylamino)phosphine; (Diisopropylamino)(tert-butoxy)chlorophosphine precursor
EINECS	Contact for details

Quality Control

Our tert-Butyl Tetraisopropylphosphorodiamidite is manufactured under strict quality systems to ensure consistency and reliability for critical synthetic applications. Each batch is subjected to rigorous analytical testing, including NMR (¹H, ³¹P) and HPLC analysis, to confirm high chemical purity and the absence of critical impurities like hydrolyzed species. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
³¹P NMR Purity	≥ 97.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.