Description

Hypercalcemia Of Malignancy Factor (107-139) (Human) CAS NO 137348-10-8 is a defined synthetic peptide fragment corresponding to a specific region of the parathyroid hormone-related protein (PTHrP). This compound is a critical research tool for investigating the mechanisms of humoral hypercalcemia of malignancy (HHM), a common paraneoplastic syndrome. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers focused on oncology, endocrinology, and bone metabolism.

Application

• Biomedical Research: Fundamental studies on the pathophysiology of cancer-induced hypercalcemia and PTHrP signaling pathways.
• Assay Development: Used as a reference standard or calibrant in the development of immunoassays (e.g., ELISA) to detect PTHrP or related antibodies.
• Drug Discovery: Screening and validation of potential therapeutic compounds designed to inhibit PTHrP activity or its receptor binding.
• Antibody Production: Acts as an immunogen for generating specific polyclonal or monoclonal antibodies against the PTHrP (107-139) epitope.
• Cell Biology Studies: Investigation of the peptide's effects on osteoclast activity, bone resorption, and calcium homeostasis in cell culture models.
• Quality Control: Serves as a system suitability standard in analytical methods for related peptide-based pharmaceuticals or diagnostics.

Basic Information

Product Name	Hypercalcemia Of Malignancy Factor (107-139) (Human)
CAS No.	137348-10-8
Molecular Formula	C164H263N51O48S
Molecular Weight	3758.2 g/mol (theoretical)
Synonyms	PTHrP (107-139), Human; Parathyroid Hormone-Related Protein (107-139); Hypercalcemic Factor of Malignancy (107-139); PTHLH (107-139); HHM Factor (107-139); PTHRP Fragment 107-139; Cancer-derived Hypercalcemic Peptide
EINECS	Contact for details

Quality Control

Our Hypercalcemia Of Malignancy Factor (107-139) (Human) is produced and analyzed under strict quality systems. Each batch undergoes rigorous testing to ensure high purity, correct sequence, and biological relevance. Standard analytical techniques include reversed-phase HPLC, mass spectrometry (MS), and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Sequence	H-Ser-Ala-Leu-Leu-Gln-His-Asp-Lys-Trp-Leu-Asn-His-Leu-Gln-Leu-Leu-Ala-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Leu-Ala-Pro-Arg-Asn-OH
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.