Description

Poneratoxin CAS NO 137084-94-7 is a potent neurotoxic peptide originally isolated from the venom of the bullet ant (*Paraponera clavata*). This compound is of significant interest for its highly specific action on voltage-gated sodium channels, leading to sustained neuronal excitation. It serves as a critical research tool in neuroscience and pharmacology for studying ion channel function, pain pathways, and insecticidal mechanisms. Key industries that utilize this high-purity biochemical include academic and pharmaceutical R&D, agrochemical development for novel insecticides, and specialized toxicology studies.

Application

• Neuroscience Research: A valuable tool for investigating the structure, function, and modulation of voltage-gated sodium channels (NaV channels) in neuronal signaling.
• Pharmacology & Drug Discovery: Used in high-throughput screening and mechanistic studies to identify and develop new analgesics, anesthetics, or channel-blocking therapeutics.
• Toxicology Studies: Employed as a reference standard in studies of arthropod venom toxicity and the physiological effects of neurotoxins.
• Agrochemical Research: Serves as a lead compound or template for the development of novel, selective bio-insecticides targeting insect nervous systems.
• Ion Channel Proteomics: Used in affinity purification and labeling studies to isolate and characterize specific sodium channel subtypes.
• Physiological Research: Applied in experimental models to study pain induction, neurotransmitter release, and excitatory mechanisms.

Basic Information

Product Name	Poneratoxin
CAS No.	137084-94-7
Molecular Formula	C₁₆₄H₂₆₅N₅₅O₅₃S₇
Molecular Weight	~3980.8 g/mol
Synonyms	Poneratoxin; Paraponera clavata toxin; Poneratoxin Peptide; Poneratoxin (Paraponera clavata); Poneratoxin (Poneratoxin); Poneratoxin (Poneratoxin (Paraponera clavata)); Poneratoxin (Poneratoxin (Poneratoxin)); Poneratoxin (Poneratoxin (Poneratoxin (Paraponera clavata))).
EINECS	Contact for details

Quality Control

Our Poneratoxin is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. We provide full traceability and documentation. Certificates of Analysis (COA) detailing purity, peptide content, and biological activity (where applicable) are available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by functional assay (data provided on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.