Description

Brain P75 Binding Protein CAS NO 136958-07-1 is a specialized biochemical reagent of significant interest in neuroscience and cell biology research. This protein plays a crucial role in modulating neurotrophin signaling pathways, particularly those involving nerve growth factor (NGF). It is an essential tool for researchers and pharmaceutical developers investigating neuronal development, survival, and neurodegenerative disease mechanisms. Key users include academic research institutions, biotechnology companies, and pharmaceutical R&D departments focused on neurobiology and drug discovery.

Application

• Neuroscience Research: Fundamental studies on neurotrophin signaling, neuronal differentiation, and apoptosis.
• Drug Discovery & Screening: Target protein for developing novel therapeutics for neurodegenerative diseases like Alzheimer's and Parkinson's.
• Biochemical Assay Development: Used as a key component in ELISA, Western blotting, and other protein interaction assays.
• Cell Culture Studies: Investigation of its effects on cell survival, growth, and death in neuronal cell lines.
• Receptor-Ligand Interaction Analysis: Studying the binding kinetics and specificity with p75 neurotrophin receptor (p75NTR).
• Diagnostic Reagent Development: Potential use in developing biomarkers for neurological conditions.

Basic Information

Product Name	Brain P75 Binding Protein
CAS No.	136958-07-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	p75 Binding Protein; p75NTR-Associated Protein; Neurotrophin Receptor Interactor; p75NTR-BP; NGF Receptor Binding Protein; Brain-Derived p75 Ligand; p75 ICD Binding Protein; Neuronal Survival Factor Modulator
EINECS	Contact for details

Quality Control

Our Brain P75 Binding Protein is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment via SDS-PAGE and HPLC, functional activity assays, and endotoxin level checks. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all relevant specifications to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 90%
Protein Content (BCA)	≥ 95% of total mass
Biological Activity	Determined by functional assay (e.g., receptor binding)
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers
Identification (IR / Mass Spec)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.