Description

Trk1 Protein CAS NO 136956-54-2 is a high-purity, biologically active recombinant protein that serves as a critical research tool in neuroscience and oncology. This product is essential for studying neurotrophin signaling pathways, particularly those mediated by the TrkA receptor, which are vital for neuronal survival, differentiation, and plasticity. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for neurological disorders and cancer.

Application

• Biochemical Research: Used as a standard or substrate in enzyme activity assays and binding studies to investigate TrkA receptor function and downstream signaling cascades.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and validate potential inhibitors or modulators of TrkA kinase activity for cancer and pain therapy development.
• Cell-Based Assays: Applied in cell culture to stimulate TrkA-expressing cell lines, enabling the study of cellular responses, proliferation, and differentiation.
• Antibody Production & Validation: Serves as a critical immunogen for generating anti-TrkA antibodies and as a positive control in Western blot, ELISA, and immunohistochemistry applications.
• Structural Biology: Provides a purified protein source for X-ray crystallography or cryo-EM studies aimed at elucidating the three-dimensional structure of TrkA for structure-based drug design.
• Diagnostic Development: Utilized in the development and calibration of diagnostic assays designed to detect TrkA fusion proteins or expression levels in clinical samples.

Basic Information

Product Name	Trk1 Protein
CAS No.	136956-54-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Recombinant TrkA Protein; Tyrosine Kinase Receptor A Protein; Neurotrophic Tyrosine Kinase Receptor Type 1; High Affinity Nerve Growth Factor Receptor; p140-TrkA; TRK1-Transforming Tyrosine Kinase Protein; Tropomyosin Receptor Kinase A; NTRK1 Protein
EINECS	Contact for details

Quality Control

Our Trk1 Protein is manufactured under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, verification of identity, and functional activity assays. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); always allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (SDS-PAGE)	Single band at expected molecular weight
Purity (HPLC)	≥ 95%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by cell-based proliferation or kinase assay
Protein Concentration	As per COA
Solubility	Soluble in appropriate aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.