Description

δ-Ava-Pro(9)-Substance P (7-11) CAS NO 136912-73-7 is a synthetic peptide fragment derived from the neuropeptide Substance P, specifically encompassing the amino acid sequence from positions 7 to 11. This compound is a critical research tool for studying the structure-activity relationships and biological functions of Substance P, particularly its interaction with neurokinin receptors. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on neuroscience, pain management, and inflammatory pathways.

Application

• Neuroscience Research: Used as a selective ligand to investigate the binding and signaling mechanisms of neurokinin-1 (NK1) receptors.
• Pharmacological Studies: Serves as a reference standard and active agent in assays for screening potential analgesic and anti-inflammatory drug candidates.
• Biochemical Analysis: Employed in structure-activity relationship (SAR) studies to understand the core active region of the full Substance P peptide.
• Cell Signaling Pathways: A key reagent in studying the role of Substance P fragments in inflammation, nociception, and immune cell modulation.
• Academic & Institutional Research: Provides a defined, high-purity peptide fragment for reproducible experimental results in university and government labs.
• Biotechnology Reagent: Used in the development and validation of diagnostic assays and biosensors targeting neuropeptide pathways.

Basic Information

Product Name	δ-Ava-Pro(9)-Substance P (7-11)
CAS No.	136912-73-7
Molecular Formula	C33H51N9O6S
Molecular Weight	701.89 g/mol
Synonyms	Substance P (7-11) fragment; [Ava9]-Substance P (7-11); H-Phe-Phe-Gly-Leu-Met-NH2 (Ava variant); δ-Aminovaleric acid9-Substance P (7-11); Neurokinin receptor ligand fragment; SP (7-11) analog; FFGLM-NH2 (Ava9); NK1 receptor peptide fragment
EINECS	Contact for details

Quality Control

Every batch of δ-Ava-Pro(9)-Substance P (7-11) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards applicable to research-grade peptides. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.