Description

Antithrombin Cambridge Ii CAS NO 136807-05-1 is a specific genetic variant of the serine protease inhibitor antithrombin, a key regulator of the blood coagulation cascade. This high-purity protein is of significant value for advanced research and diagnostic development in the fields of hematology and thrombosis. It is primarily required by biotechnology companies, clinical research organizations, and diagnostic manufacturers for applications in biochemical research, assay development, and as a critical reference standard.

Application

• Biochemical Research & Development: Used as a critical reagent in studies of blood coagulation mechanisms, serine protease inhibition, and structure-function relationships of antithrombin variants.
• Diagnostic Assay Development: Serves as a purified antigen or reference standard in the development and calibration of immunoassays (e.g., ELISA) for detecting antithrombin levels or specific mutations.
• Quality Control Reference: Employed as a benchmark material in pharmaceutical QC laboratories to validate assays for antithrombin-based therapeutics or plasma-derived products.
• Thrombophilia Research: Essential for investigating the link between specific antithrombin mutations (like Cambridge II) and inherited thrombophilia, aiding in genetic and clinical studies.
• Enzyme Kinetics Studies: Utilized to study the kinetics of thrombin and Factor Xa inhibition, providing insights into anticoagulant pathways.
• Pharmaceutical Intermediates: Acts as a high-purity starting material or intermediate for further processing in the development of specialized biopharmaceuticals.

Basic Information

Product Name	Antithrombin Cambridge Ii
CAS No.	136807-05-1
Molecular Formula	Contact for details
Molecular Weight	~58 kDa (Approx., glycosylated protein)
Synonyms	Antithrombin III Cambridge II; ATIII Cambridge II; SerpinC1 Cambridge II variant; Antithrombin variant (Ala384Ser); AT Cambridge II; Antithrombin (type II) variant; Antithrombin III (mutant)
EINECS	Contact for details

Quality Control

Our Antithrombin Cambridge Ii is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional activity. We adhere to relevant guidelines for research-grade biological materials to ensure reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE)	Single band corresponding to ~58 kDa
Purity (HPLC)	≥ 95%
Protein Content	≥ 90% (Biuret or similar)
Biological Activity (Anti-Factor Xa)	Contact for details
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in water or appropriate buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.