Description

Buprenorphine-D4 is a deuterated internal standard of the potent opioid partial agonist buprenorphine, specifically labeled with four deuterium atoms. This compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors who require precise measurement of buprenorphine levels.

Application

• Primary use as a stable isotope-labeled internal standard for the quantitative analysis of buprenorphine via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Critical component in pharmacokinetic and metabolism studies to track drug absorption, distribution, and excretion.
• Essential for forensic and clinical toxicology testing, ensuring accurate results in drug monitoring and overdose cases.
• Used in the development and validation of analytical methods for buprenorphine in compliance with regulatory guidelines (e.g., FDA, EMA).
• Supporting bioequivalence studies for generic buprenorphine formulations.
• Application in research on opioid dependence treatment, aiding in the precise measurement of drug and metabolite concentrations.

Basic Information

Product Name	Buprenorphine-D4
CAS No.	136781-89-0
Molecular Formula	C29H37D4NO4
Molecular Weight	471.66 g/mol
Synonyms	Buprenorphine-d4; (2S)-2-[17-(Cyclopropylmethyl)-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol-d4; 21,21,22,22-Tetradeuterobuprenorphine; Buprenorphine (D4); Deuterated Buprenorphine Internal Standard
EINECS	Contact for details

Quality Control

Our Buprenorphine-D4 is manufactured under strict quality control protocols to ensure the highest chemical purity and isotopic enrichment, which are critical for its function as an analytical standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and other critical parameters. We support compliance with GMP/GLP principles for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.