Description

(+)-1,2-Bis[(2S,5S)-2,5-Diethylphospholano]Benzene CAS NO 136779-28-7 is a high-value, chiral bisphosphine ligand of significant importance in asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalysis: A premier ligand for the enantioselective hydrogenation of dehydroamino acids, enamides, ketones, and other unsaturated substrates in pharmaceutical intermediate synthesis.
• Pharmaceutical Intermediate Manufacturing: Critical for the production of chiral active pharmaceutical ingredients (APIs), including those for cardiovascular, central nervous system, and antiviral drugs.
• Agrochemical Synthesis: Used in the asymmetric synthesis of chiral herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Fine Chemical Production: Enables the synthesis of enantiomerically pure flavors, fragrances, and specialty chemicals.
• Academic & Industrial R&D: A vital tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Catalyst Library Development: Serves as a key component in high-throughput screening and catalyst optimization for contract research organizations (CROs) and catalyst suppliers.

Basic Information

Product Name	(+)-1,2-Bis[(2S,5S)-2,5-Diethylphospholano]Benzene
CAS No.	136779-28-7
Molecular Formula	C24H40P2
Molecular Weight	390.52 g/mol
Synonyms	(S,S)-Et-DuPhos; (2S,2'S,5S,5'S)-1,1'-(1,2-Phenylene)bis(2,5-diethylphospholane); (+)-1,2-Bis((2S,5S)-2,5-diethylphospholanyl)benzene; (S,S)-1,2-Bis(2,5-diethylphospholano)benzene; DuPhos ligand derivative; Et-DuPhos; Chiral bisphospholane ligand
EINECS	Contact for details

Quality Control

Every batch of (+)-1,2-Bis[(2S,5S)-2,5-Diethylphospholano]Benzene is manufactured and tested under strict quality management systems. We ensure high chiral purity and chemical integrity through advanced analytical techniques including NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with each shipment to guarantee consistency and reliability for your critical catalytic processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. Keep the container in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (e.g., THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.