Description

(-)-1,2-Bis((2S,5S)-2,5-Diethylphospholano)Ethane is a high-value, chiral bisphosphine ligand essential for creating highly selective asymmetric catalysts. Its precise stereochemistry enables superior enantioselectivity and catalytic activity in critical synthetic transformations. This ligand is indispensable for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require advanced chiral intermediates.

Application

• As a key ligand in asymmetric hydrogenation reactions for the synthesis of chiral pharmaceutical intermediates.
• Catalyst component for enantioselective C-C bond formation processes, including cross-coupling and allylic substitution.
• Critical for the production of optically pure amino acids, amines, and alcohols used in active pharmaceutical ingredients (APIs).
• Enabling technology in the synthesis of agrochemicals and flavors & fragrances requiring specific stereochemistry.
• Research and development of novel homogeneous catalysts for academic and industrial applications.
• Scale-up manufacturing of complex fine chemicals where yield and enantiomeric excess (ee) are critical.

Basic Information

Product Name	(-)-1,2-Bis((2S,5S)-2,5-Diethylphospholano)Ethane
CAS No.	136779-27-6
Molecular Formula	C20H40P2
Molecular Weight	342.47 g/mol
Synonyms	(S,S)-Et-DuPhos; (2S,2'S,5S,5'S)-1,1'-Diethyl-2,2',5,5'-tetrahydro-1,1'-biphosphole; (-)-1,2-Bis((2S,5S)-2,5-Diethylphospholan-1-yl)ethane; (S,S)-1,2-Bis(2,5-diethylphospholano)ethane; Et-DuPhos ligand; (S,S)-Et-DuPhos ligand; DuPhos-Et ligand; Chiral bisphospholane ligand
EINECS	Contact for details

Quality Control

Our production of (-)-1,2-Bis((2S,5S)-2,5-Diethylphospholano)Ethane adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is fully characterized and supplied with a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical assay, and identity confirmation. We support cGMP and ISO-aligned manufacturing for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is air- and moisture-sensitive; handle and open containers only in a controlled, dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.