Description

(-)-1,2-Bis((2S,5S)-2,5-Dimethylphospholano)Ethane is a high-value, chiral bisphosphine ligand essential for creating highly selective asymmetric catalysts. Its core value lies in enabling precise stereochemical control in hydrogenation and other transition metal-catalyzed reactions, which is critical for producing enantiomerically pure intermediates. This ligand is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development and production of active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• As a key ligand in asymmetric hydrogenation catalysts for pharmaceutical synthesis.
• For the production of enantiomerically pure intermediates in fine chemical manufacturing.
• In academic and industrial research for developing novel catalytic processes.
• As a chiral auxiliary in the synthesis of complex natural products and agrochemicals.
• For catalyst screening and optimization in process chemistry development.

Basic Information

Product Name	(-)-1,2-Bis((2S,5S)-2,5-Dimethylphospholano)Ethane
CAS No.	136779-26-5
Molecular Formula	C14H28P2
Molecular Weight	258.32 g/mol
Synonyms	(-)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)ethane; (S,S)-Skewphos; (S,S)-Me-DuPhos; (2S,2'S,5S,5'S)-1,1'-(1,2-Ethanediyl)bis[2,5-dimethylphospholane]; DuPhos ligand derivative; Chiral C2-symmetric bisphospholane; (S,S)-1,2-Bis(2,5-dimethylphospholano)ethane; Ligand for asymmetric hydrogenation
EINECS	Contact for details

Quality Control

Our (-)-1,2-Bis((2S,5S)-2,5-Dimethylphospholano)Ethane is produced under strict quality management protocols to ensure high chemical and chiral purity, which is critical for catalytic performance. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters are provided to guarantee consistency and support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, containers should be kept sealed and only opened in an inert environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (ee)	≥ 98.0%
Moisture (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.